RNF126 Rabbit Polyclonal Antibody

CAT#: TA386806

RNF126 Rabbit polyclonal antibody



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ug

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经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Reactivity Mouse, Human
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant Human E3 ubiquitin-protein ligase RNF126 protein (39-225AA)
Formulation Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Concentration lot specific
Purification >95%, Protein G purified
Conjugation Unconjugated
Storage Condition Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Background E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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