GABA A Receptor alpha 1 (GABRA1) Mouse Monoclonal Antibody [Clone ID: 1F4]
CNY 6,881.00
货期*
6周
规格
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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
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Specifications
Product Data | |
Clone Name | 1F4 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | This antibody was raised against α1β2γ2 GABA-A receptor. |
Specificity | This antibody recognises α1β2γ2 GABA-A receptor which is found in up to 50% of the synapses in the brain. It's ligand, GABA is a major inhibitory transmitter in the nervous system, binds to this receptor and opens a channel permeable to chloride. Disfunctions of GABAR are found in anxiety, neurodevelopmental disorderds and epilepsy. FSEC: High affinity and specificity of the 1F4 antibody to α1β2γ2 GABA-A receptor was demonstrated using fluorescence-detection size exclusion chromatography with GFP-tagged receptor (shift in elution volume) (Zhu et al., 2018). Crystallography: Furthermore, this antibody was utilised in production and purification of the α1β2γ2 GABA-A receptor (Zhu et al., 2018). Finally, Fab fragments derived from the antibody were used to facilitate crystallisation and improve stabilisation of the α1β2γ2 GABA-A receptor (Zhu et al., 2018). |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Gene Name | gamma-aminobutyric acid type A receptor alpha1 subunit |
Database Link | |
Synonyms | ECA4; EJM; EJM5 |
Reference Data |
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