CD64 (FCGR1A) Human Monoclonal Antibody [Clone ID: H22]
CNY 6,881.00
货期*
6周
规格
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经常一起买 (1)
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CNY 300.00
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Specifications
Product Data | |
Clone Name | H22 |
Applications | CT, FC |
Reactivity | Human |
Host | Human |
Clonality | Monoclonal |
Immunogen | This recombinant antibody was prepared by cloning the single chain fragment (scFv) derived from the murine anti-human CD64 mAb m22 into the bacterial expression vector pBM1.1, and fusing it to a deletion mutant of Pseudomonas exotoxin A (ETA). |
Specificity | This immunotoxin is specific for human CD64, and specifically an epitope outside the Fc binding domain. The binding activity of the VH/VL antibody format was unaffected by fusion of the m22(scFv) coding regions to the truncated ETA coding sequences This antibody binds human CD64 and can be bound to a toxin so that together it displays specific cytotoxicity, and thus can be used to selectively eliminate AML cells; FC analysis indicated that this immunotoxin drove 41% of primary leukemia cells from a patient with CD64-positive AML into early apoptosis (Tur, 2003). Similarly, in an in vivo mouse model, IHC analysis revealed efficient elimination of human CD64+ tumor cells in mouse organs (Tur, 2011). |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Gene Name | Fc fragment of IgG receptor Ia |
Database Link | |
Synonyms | CD64; CD64A; FCG1; FCGR1; FcRI; FLJ18345; IGFR1 |
Note | This chimeric human antibody was made using the variable domain sequences of the original IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
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