F Human Monoclonal Antibody [Clone ID: RSHZ19 (Felvizumab)]

Specifications

Product Data
Clone Name	RSHZ19 (Felvizumab)
Applications	ELISA, FN
Reactivity	Respiratory Syncytial Virus
Host	Human
Clonality	Monoclonal
Immunogen	This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
Specificity	This antibody is specific for the conserved fusion (F) protein of RSV. Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Reference Data

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