Folr2 Rat Monoclonal Antibody [Clone ID: CL10]

Specifications

Product Data
Clone Name	CL10
Applications	IHC, WB
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	FRβ_x0001_-transfected RBL2H3 cells.
Specificity	The antibody binds specifically to FRβ, a member of the folate receptor family. The receptor binds with high affinity to folic acid and folic acid derivatives, and transports 5-methyltetrahydrofolate into the cell. The receptor is expressed on the surface of tumour associated macrophages (TAMs) that promote growth and metastasis of tumours such as gliomas and colon, breast and lung carcinomas. Research has shown FRβ is only expressed on activated macrophages, and thereby a monoclonal antibody that targets the receptor can be useful in the diagnosis of the cancer. Furthermore, the antibody may be conjugated with a toxin, delivering the drug only to TAMs and not to healthy macrophages.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	folate receptor 2 (fetal)
Database Link	Entrez Gene 14276 Mouse UniProt ID Q05685
Synonyms	BETA-HFR; FBP; FBP/PL-1; FR-BETA; FR-P3
Reference Data

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