Kaiso (ZBTB33) Rabbit Monoclonal Antibody [Clone ID: R05-5J5]

Specifications

Product Data
Clone Name	R05-5J5
Applications	WB
Recommend Dilution	WB: 1/1000-1/5000
Reactivity	Human, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Kaiso
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 75 kDa; Observed MW: 90 kDa
Gene Name	zinc finger and BTB domain containing 33
Database Link	Entrez Gene 10009 Human UniProt ID Q86T24
Background	Swiss-Prot Acc.Q86T24.Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
Synonyms	KAISO; WUGSC:H_DJ525N14.1; ZNF-kaiso; ZNF348
Reference Data

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