Exportin 4 (XPO4) Rabbit Monoclonal Antibody [Clone ID: R09-1A2]

Specifications

Product Data
Clone Name	R09-1A2
Applications	IP, WB
Recommend Dilution	WB: 1/1000-1/5000 IP: 1/20-1/50
Reactivity	Human, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Exportin 4
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 130 kDa; Observed MW: 130 kDa
Gene Name	exportin 4
Database Link	Entrez Gene 64328 Human UniProt ID Q9C0E2
Background	Swiss-Prot Acc.Q9C0E2.Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Synonyms	Exp4; FLJ13046; KIAA1721
Reference Data

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