ULK3 Rabbit Monoclonal Antibody [Clone ID: R08-7J3]

Specifications

Product Data
Clone Name	R08-7J3
Applications	WB
Recommend Dilution	WB: 1/1000-1/5000
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human ULK3
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 53 kDa; Observed MW: 53 kDa
Gene Name	unc-51 like kinase 3
Database Link	Entrez Gene 25989 Human UniProt ID Q6PHR2
Background	Swiss-Prot Acc.Q6PHR2.Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Synonyms	DKFZP434C131; FLJ90566
Reference Data

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