TSG101 Rabbit Monoclonal Antibody [Clone ID: R01-4D9]
CAT#: TA385476S
TSG101 Rabbit monoclonal Antibody
Size: 100 ul
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Specifications
Product Data | |
Clone Name | R01-4D9 |
Applications | IF, IHC, WB |
Recommend Dilution | WB: 1/1000 IHC: 1/100 ICC/IF: 1/20 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | A synthetic peptide of human TSG101 |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Predicted Protein Size | Calculated MW: 44 kDa; Observed MW: 44 kDa |
Gene Name | tumor susceptibility 101 |
Database Link | |
Background | Swiss-Prot Acc.Q99816.Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). |
Synonyms | TSG10; VPS23 |
Reference Data |
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