SF3B3 Rabbit Monoclonal Antibody [Clone ID: R07-2K8]

Specifications

Product Data
Clone Name	R07-2K8
Applications	IF, WB
Recommend Dilution	WB: 1/1000 ICC/IF: 1/50
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human SF3B3
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 136 kDa; Observed MW: 136 kDa
Gene Name	splicing factor 3b subunit 3
Database Link	Entrez Gene 23450 Human UniProt ID Q15393
Background	Swiss-Prot Acc.Q15393.Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).
Synonyms	KIAA0017; RSE1; SAP130; SF3b130; STAF130
Reference Data

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