Rb2 p130 (RBL2) Rabbit Monoclonal Antibody [Clone ID: R02-5D6]

CAT#: TA385145S

Phospho-Rb2 p130 (Ser952) Rabbit monoclonal Antibody

Size: 20 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 20 ul

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Specifications

Product Data
Clone Name R02-5D6
Applications IF, IHC, WB
Recommend Dilution WB: 1/2000-1/10000
IHC: 1/20-1/100
ICC/IF: 1/20-1/100
Reactivity Human
Host Rabbit
Clonality Monoclonal
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser952 of human Rb2 p130 (Phosphorylated)
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size Calculated MW: 128 kDa; Observed MW: 130 kDa
Gene Name RB transcriptional corepressor like 2
Background Swiss-Prot Acc.Q08999.Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Synonyms FLJ26459; p130; PRB2; Rb2; RBR-2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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