PYK2 (PTK2B) Mouse Monoclonal Antibody [Clone ID: 4B4-D0-F3]

Specifications

Product Data
Clone Name	4B4-D0-F3
Applications	IHC, WB
Recommend Dilution	WB: 1/500-1/2000 IHC: 1/200-1/1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Ascitic Fluid
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	115.8kDa
Gene Name	protein tyrosine kinase 2 beta
Database Link	Entrez Gene 2185 Human UniProt ID Q14289
Background	Swiss-Prot Acc.Q14289.PYK2: PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, PKB, PTK, CAKB, FAK2, FRNK. Entrez Protein NP_004094. It is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Synonyms	CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK
Reference Data

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