COX2 (PTGS2) Rabbit Monoclonal Antibody [Clone ID: R04-3I1]

Specifications

Product Data
Clone Name	R04-3I1
Applications	IHC, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human COX2
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 69 kDa; Observed MW: 69 kDa
Gene Name	prostaglandin-endoperoxide synthase 2
Database Link	Entrez Gene 5743 Human UniProt ID P35354
Background	Swiss-Prot Acc.P35354.Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Synonyms	COX-2; COX2; Cyclooxygenase-2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; PHS-2
Reference Data

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