NUMB Rabbit Monoclonal Antibody [Clone ID: R09-2I5]

Specifications

Product Data
Clone Name	R09-2I5
Applications	IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/200 IP: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human NUMB
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 71 kDa; Observed MW: 71 kDa
Gene Name	NUMB, endocytic adaptor protein
Database Link	Entrez Gene 8650 Human UniProt ID P49757
Background	Swiss-Prot Acc.P49757.Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Synonyms	h-Numb; S171
Reference Data

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