IRF1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, IHC, IP, WB
Recommend Dilution	WB: 1/500-1/1000 IHC: 1/50-1/100 ICC/IF: 1/50-1/100 IP: 1/50 FC: 1/50
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthesized peptide derived from human IRF1
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	48kDa
Gene Name	interferon regulatory factor 1
Database Link	Entrez Gene 3659 Human UniProt ID P10914
Background	Swiss-Prot Acc.P10914.Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor. Defects in IRF1 are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer inTinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small inTine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body.
Synonyms	IRF-1; MAR; OTTHUMP00000198266
Reference Data

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