IFNAR1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IP, WB
Recommend Dilution	WB: 1/500-1/2000 IP: 1/50 FC: 1/50
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthesized peptide derived from human IFNAR1
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	90,130kDa
Gene Name	interferon alpha and beta receptor subunit 1
Database Link	Entrez Gene 3454 Human UniProt ID P17181
Background	Swiss-Prot Acc.P17181.Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
Synonyms	AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC
Reference Data

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