FGFR4 Mouse Monoclonal Antibody [Clone ID: 7H1]

Specifications

Product Data
Clone Name	7H1
Applications	IF
Recommend Dilution	ICC: 1/200-1/1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Ascitic Fluid
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	87.9kDa
Gene Name	fibroblast growth factor receptor 4
Database Link	Entrez Gene 2264 Human UniProt ID P22455
Background	Swiss-Prot Acc.P22455.FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms,as indicated for members 1-3. This particular family member preferentially binds acidic fibroblastgrowth factor and, although its specific function is unknown, it is overexpressed in gynecologicaltumor samples, suggesting a role in breast and ovarian tumorigenesis.
Synonyms	CD334; FGFR-4; JTK2; MGC20292; OTTHUMP00000161430; TKF
Reference Data

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