DNAJB6 Rabbit Monoclonal Antibody [Clone ID: R01-8K2]

Specifications

Product Data
Clone Name	R01-8K2
Applications	IHC, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human DNAJB6
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 36 kDa; Observed MW: 36 kDa
Gene Name	DnaJ heat shock protein family (Hsp40) member B6
Database Link	Entrez Gene 10049 Human UniProt ID O75190
Background	Swiss-Prot Acc.O75190.Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
Synonyms	DJ4; DKFZp566D0824; DnaJ; FLJ42837; HHDJ1; HSJ-2; HSJ2; MGC1152; MGC117297; MRJ; MSJ-1; MSJ1
Reference Data

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