DIABLO Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, IHC, IP, WB
Recommend Dilution	WB: 1/1000-1/5000 IHC: 1/50-1/200 ICC/IF: 1/100-1/500 IP: 1/50 FC: 1/50
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthesized peptide derived from human Smac/Diablo
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	21kDa
Gene Name	diablo IAP-binding mitochondrial protein
Database Link	Entrez Gene 56616 Human UniProt ID Q9NR28
Background	Swiss-Prot Acc.Q9NR28.Smac/Diablo is a 21 kDa mammalian mitochondrial protein that functions as a regulatory component during apoptosis. Upon mitochondrial stress, Smac/Diablo is released from mitochondria and competes with caspases for binding of IAPs (inhibitor of apoptosis proteins). The interaction of Smac/Diablo with IAPs relieves the inhibitory effect of the IAPs on caspases.
Synonyms	0610041G12Rik; DIABLO-S; FLJ10537; FLJ25049; SMAC; SMAC3
Reference Data

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