CYP1B1 Rabbit Monoclonal Antibody [Clone ID: R02-5A3]

Specifications

Product Data
Clone Name	R02-5A3
Applications	IHC, WB
Recommend Dilution	WB: 1/2000 IHC: 1/50
Reactivity	Human, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human CYP1B1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 61 kDa; Observed MW: 61 kDa
Gene Name	cytochrome P450 family 1 subfamily B member 1
Database Link	Entrez Gene 1545 Human UniProt ID Q16678
Background	Swiss-Prot Acc.Q16678.Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
Synonyms	CP1B; CYPIB1; GLC3A; OTTHUMP00000201401; P4501B1
Reference Data

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