Chk2 (CHEK2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, IP, WB
Recommend Dilution	WB: 1/10000-1/20000 IHC: 1/50-1/200 ICC/IF: 1/50-1/200 IP: 1/50
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthesized peptide derived from human Chk2
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	62kDa
Gene Name	checkpoint kinase 2
Database Link	Entrez Gene 11200 Human UniProt ID O96017
Background	Swiss-Prot Acc.O96017.These are known to be preferred sites for phosphorylation by ATM/ATR kinases. After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function.
Synonyms	bA444G7; CDS1; CHK2; HuCds1; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199116; PP1425; RAD53
Reference Data

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