Caspase 3 (CASP3) Rabbit Monoclonal Antibody [Clone ID: R08-6F2]

Specifications

Product Data
Clone Name	R08-6F2
Applications	IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/50 IP: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human Caspase-3
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 32 kDa; Observed MW: 32 kDa
Gene Name	caspase 3
Database Link	Entrez Gene 836 Human UniProt ID P42574
Background	Swiss-Prot Acc.P42574.Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Synonyms	apopain; CASP-3; CPP-32; CPP32; CPP32B; procaspase3; SCA-1; Yama
Reference Data

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