Bcl x (BCL2L1) Rabbit Monoclonal Antibody [Clone ID: R02-2D3]

CAT#: TA383814S

Bcl-XL Rabbit monoclonal Antibody

Size: 20 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 20 ul

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    • 30 ul

CNY 300.00
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Specifications

Product Data
Clone Name R02-2D3
Applications IF, IHC, IP, WB
Recommend Dilution WB: 1/1000
IHC: 1/200
ICC/IF: 1/200
IP: 1/20
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Immunogen Recombinant protein of human Bcl-XL
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size Calculated MW: 26 kDa; Observed MW: 30 kDa
Gene Name BCL2 like 1
Background Swiss-Prot Acc.Q07817.Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Synonyms Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; Bcl2-L-1; BCL2L; BCLX; DKFZp781P2092; OTTHUMP00000030550
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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