BAG3 Rabbit Monoclonal Antibody [Clone ID: R05-6D5]

Specifications

Product Data
Clone Name	R05-6D5
Applications	WB
Recommend Dilution	WB: 1/1000
Reactivity	Human, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human Bag3
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 62 kDa; Observed MW: 80 kDa
Gene Name	BCL2 associated athanogene 3
Database Link	Entrez Gene 9531 Human UniProt ID O95817
Background	Swiss-Prot Acc.O95817.Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
Synonyms	BAG-3; BIS; CAIR-1; MGC104307
Reference Data

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