ATP6V0D1 Rabbit Monoclonal Antibody [Clone ID: R07-1A5]

Specifications

Product Data
Clone Name	R07-1A5
Applications	IF, IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20 ICC/IF: 1/50 IP: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human ATP6V0D1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 40 kDa; Observed MW: 40 kDa
Gene Name	ATPase H+ transporting V0 subunit d1
Database Link	Entrez Gene 9114 Human UniProt ID P61421
Background	Swiss-Prot Acc.P61421.Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis . May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).
Synonyms	ATP6D; ATP6DV; P39; VATX; Vma6; VPATPD
Reference Data

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