RIC8 (RIC8A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB,1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Modifications	Unmodified
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 362-531 of human RIC8A (NP_001273063.1).
Formulation	Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	58kDa/59kDa/60kDa
Gene Name	RIC8 guanine nucleotide exchange factor A
Database Link	Entrez Gene 60626 Human UniProt ID Q9NPQ8
Background	Guanine nucleotide exchange factor (GEF, which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i-alpha protein, possibly leading to release G(i-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i-alpha-GDP complex (By similarity. Also acts as an activator for G(q-alpha (GNAQ protein by enhancing the G(q-coupled receptor-mediated ERK activation.
Synonyms	MGC104517; MGC131931; MGC148073; MGC148074; RIC8; synembryn
Reference Data

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