Glucocorticoid Receptor (NR3C1) Rabbit Polyclonal Antibody
CAT#: TA379298
Phospho-Glucocorticoid Receptor-S211 Rabbit polyclonal Antibody
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CNY 2,900.00
货期*
2周
规格
经常一起买 (1)
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB,1:1000 - 1:2000 |
Reactivity | Human, Mouse |
Modifications | Phospho S211 |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic phosphorylated peptide around S211 of human Glucocorticoid Receptor (NP_000167.1). |
Formulation | PBS with 0.05% proclin300,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 49-85kDa |
Gene Name | nuclear receptor subfamily 3 group C member 1 |
Database Link | |
Background | This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). |
Synonyms | GCCR; GCR; GR; GRL |
Reference Data |
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