EIF4G1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB,1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Modifications	Phospho S1108
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic phosphorylated peptide around S1108 of human EIF4G1 (NP_001181875.1).
Formulation	Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	154kDa/158kDa/166kDa/171kDa/175kDa/176kDa
Gene Name	eukaryotic translation initiation factor 4 gamma 1
Database Link	Entrez Gene 1981 Human UniProt ID Q04637
Background	The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.
Synonyms	DKFZp686A1451; eIF-4G1; EIF4-gamma; EIF4F; EIF4G; EIF4GI; p220
Reference Data

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