Beta TRCP (BTRC) Rabbit Polyclonal Antibody
CAT#: TA374113
β-TrCP/BTRC Rabbit polyclonal Antibody
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货期*
2周
规格
经常一起买 (1)
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Specifications
Product Data | |
Applications | ICC/IF, IHC, WB |
Recommend Dilution | WB,1:500 - 1:2000 IHC,1:50 - 1:200 IF,1:50 - 1:200 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human β-TrCP/BTRC. |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 68kDa |
Gene Name | beta-transducin repeat containing E3 ubiquitin protein ligase |
Database Link | |
Background | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. |
Synonyms | BETA-TRCP; beta-TrCP1; betaTrCP; bTrCP; bTrCP1; E3RSIkappaB; FBW1A; FBXW1; FBXW1A; FWD1; MGC4643 |
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