ALKBH8 Rabbit Polyclonal Antibody
CAT#: TA373466
ALKBH8 Rabbit polyclonal Antibody
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CNY 1,999.00
CNY 3,280.00
货期*
2周
规格
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Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | WB,1:500 - 1:2000 IHC,1:100 - 1:200 |
Reactivity | Human, Mouse, Rat |
Modifications | Unmodified |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human ALKBH8 (NP_620130.2). |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 25kDa/27kDa/75kDa |
Gene Name | alkB homolog 8, tRNA methyltransferase |
Database Link | |
Background | Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg and tRNA(Glu, and does not bind tRNA(Lys(PubMed:20308323. Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly. Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis. |
Synonyms | ABH8; FLJ38204; MGC10235; OTTHUMP00000211286; OTTHUMP00000211287 |
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