TMP21 (TMED10) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-5000 WB positive control: NIH/3T3 cell, Mouse Pancreas tissue, Rat lung tissue, Mouse liver tissue, Hela, Raji cell lysates IHC: 50-200 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human TMED10
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	25 kDa
Gene Name	transmembrane p24 trafficking protein 10
Database Link	Entrez Gene 10972 Human UniProt ID P49755
Background	This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
Synonyms	P24(DELTA); p24delta; S31I125; S31III125; Tmp-21-I; TMP21
Reference Data

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