STK32A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse heart tissue lysate IHC: 100-200 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human STK32A
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	46 kDa
Gene Name	serine/threonine kinase 32A
Database Link	Entrez Gene 202374 Human UniProt ID Q8WU08
Background	The phosphorylation of proteins by protein kinases and protein phosphatases is a key event in most nuclear and cytoplasmic processes. The ability to activate and deactivate proteins via phosphorylation or dephosphorylation is important for cell division, cell differentiation, DNA repair and transcription. STK32A (serine/threonine kinase 32A), also known as YANK1, is a 396 amino acid protein that belongs to the superfamily of serine/threonine protein kinases and exists as three isoforms. The gene encoding STK32A maps to human chromosome 5, which is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Synonyms	A930015B13Rik; MGC22688; YANK1
Reference Data

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