SHC (SHC1) Rabbit Polyclonal Antibody
CAT#: TA370216S
SHC1 rabbit polyclonal antibody
Size: 100 ul
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Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | WB: 200-1000 WB positive control: Hela, HEPG2, NIH/3T3, 293T, Jurkat, RAW264.7 and 231 cell lysates IHC: 25-100 Positive control: Human cervical cancer Predicted cell location: Cytoplasm |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Fusion protein of human SHC1 |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C. |
Predicted Protein Size | 63 kDa |
Gene Name | SHC adaptor protein 1 |
Database Link | |
Background | This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. |
Synonyms | FLJ26504; OTTHUMP00000035472; p66; SHC; SHCA |
Reference Data |
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