ZKSCAN3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela cell, Mouse spleen tissue lysates IHC: 50-200 Positive control: Human colorectal cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human ZKSCAN3
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	61 kDa
Gene Name	zinc finger with KRAB and SCAN domains 3
Database Link	Entrez Gene 80317 Human UniProt ID Q9BRR0
Background	Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
Synonyms	dJ874C20.1; FLJ33906; KIAA0426; OTTHUMP00000016204; ZF47; Zfp-47; Zfp47; ZFP306; ZNF306; ZNF309; ZSCAN13
Reference Data

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