MRG15 (MORF4L1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 30-150 Positive control: Human lung cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human MORF4L1
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Gene Name	mortality factor 4 like 1
Database Link	Entrez Gene 10933 Human UniProt ID Q9UBU8
Background	The members of the mortality factor family include mortality factor 4 (MORF4), MORF4L1 (also known as MRG15) and MORF4-related gene X (MRGX). The human MORF4 gene maps to chromosome 4q33-q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. The genes encoding MRG15 and MRGX map to chromosomes 15q24 and Xq22, respectively. MORF4, MORF4L1 and MRGX each contain a C-terminal leucine zipper. An association between MORF4L1, Rb (retinoblastoma tumor suppressor) and PAM14 (protein associated with MORF4L1) suggests a role for MORF4L1 in transcription regulation. MORF4L1 also associates with the histone acetyl transferase MOF. In addition, MORF4 and MRGX interact with mSin3A and TLE (transducin-like enhancer of split). The MORF/ mSin3A/TLE association may repress transcription. In Purkinje cells, MORF4L1 localizes to the dendrites and the nuclei.
Synonyms	Eaf3; FWP006; HsT17725; MEAF3; MGC10631; MORFRG15; MRG15; S863-6
Reference Data

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