AF9 (MLLT3) Rabbit Polyclonal Antibody
CAT#: TA364584S
MLLT3 rabbit polyclonal antibody
Size: 100 ul
Need it in bulk or conjugated?
Get a free quote
CNY 800.00
CNY 1,280.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1000-5000 WB positive control: HepG2, 293T, K562 cell lysates |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Fusion protein of human MLLT3 |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C. |
Predicted Protein Size | 63 kDa |
Gene Name | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 |
Database Link | |
Background | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3. In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones. |
Synonyms | AF-9; AF9; FLJ2035; YEATS3 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |