Endothelin 1 (EDN1) Rabbit Polyclonal Antibody
CAT#: TA364232
Rabbit polyclonal anti Big Endothelin-1 (hu); purified rabbit IgG
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CNY 10,313.00
货期*
5周
规格
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Specifications
Product Data | |
Applications | ELISA |
Recommend Dilution | This antibody has been tested and validated in ELISA against Big Endothelin-1. Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys- Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val- Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH (Disulfide bridge: 1 - 15 and 3 - 11) coupled to carrier protein. |
Formulation | Protein A affinity purified from antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 0.2ml distilled water. This stock solution contains 2mg/ml IgG, phosphate buffer saline pH 7.4 (PBS), and 0.02% (w/v) Thimerosal as a preservative. |
Concentration | N/A |
Conjugation | Unconjugated |
Storage Condition | Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below. |
Gene Name | endothelin 1 |
Database Link | |
Background | Big Endothelin-1 (Big ET), is a 38-amino-acid peptide and biological precursor of the potent vasoconstrictor Endothelin-1. It is cleaved to yield endothelin-1 and the C-terminal fragment (22-38) via the activity of a membrane-bound metalloproteinase called endothelin-converting enzyme (ECE). Endothelin is produced by several cell types including vascular endothelial cells, Mesangial cells and kidney cells. Big Endothelin-1 can be hydrolyzed by chymase to generate endothelin 1 (1-21) in vitro. This antibody was generated by immunization of rabbits with Big Endothelin-1 coupled to a carrier protein. |
Synonyms | ET1; HDLCQ7; PPET1; Preproendothelin-1 |
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