SIGIRR Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR
Specificity	Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rat, Zebrafish Homology: Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86%
Formulation	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted Protein Size	25kDa
Gene Name	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Database Link	Entrez Gene 59307 Human UniProt ID Q6IA17
Background	SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
Synonyms	MGC110992; TIR8
Reference Data

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