Rb (RB1) Mouse Monoclonal Antibody [Clone ID: 13A10]

Specifications

Product Data
Clone Name	13A10
Applications	IHC, WB
Recommend Dilution	IHC: 1:25 - 1:50 WB: 1:250
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant prokaryotic protein corresponding to a portion of the N-terminal region of the retinoblastoma gene product
Specificity	Human retinoblastoma gene protein (105 kD)
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	RB transcriptional corepressor 1
Database Link	Entrez Gene 5925 Human UniProt ID P06400
Background	Retinoblastoma (Rb) is a rare tumor of the retina associated with mutations of chromosome 13. The nuclear phosphoprotein encoded by the Rb tumor suppressor gene is present in many cells and may indirectly regulate cell growth by activating the transcription factor ATF-2. Activation of ATF-2 initiates expression of TGF-beta2, which in turn inhibits transcription of genes affecting cell growth. Bilateral mutation of the Rb gene may potentially play a role in the development of a number of malignant tumors.
Synonyms	OSRC; osteosarcoma; p105-Rb; pp110; pRb; RB
Reference Data

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