PLK1 Mouse Monoclonal Antibody [Clone ID: MJS1]

Specifications

Product Data
Clone Name	MJS1
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	107 amino acids from central region of human PLK-1 protein
Specificity	Human PLK-1 protein
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	polo like kinase 1
Database Link	Entrez Gene 5347 Human UniProt ID P53350
Background	Polo-Like Kinase-1 (PLK1) also known as Serine/Threonine Protein Kinase 13) is a 66 kDa kinase. The activity of PLK-1 is crucial for mitosis and maintenance of genome stability. PLK-1 localizes to centrosomes and kinetochores where it plays a key role in late prophase and prometaphase. PLK-1 is overexpressed in many types of cancers and mediates estrogen receptor-mediated gene transcription in breast cancer cells. Overexpression of PLK-1 is associated with tumor development, with elevated levels of expression reported in non-small cell lung cancers, head and neck, gastric, breast, ovarian, colon and several other cancer types.
Synonyms	PLK; PLK-1; STPK13
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.