Perforin (PRF1) Mouse Monoclonal Antibody [Clone ID: 5B10]

Specifications

Product Data
Clone Name	5B10
Applications	IHC
Recommend Dilution	1:20
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant prokaryotic protein corresponding to an external region of the C-terminus of the perforin molecule
Specificity	Human perforin. Shows cross-reactivity with smooth muscle and differentiated epithelium
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	perforin 1
Database Link	Entrez Gene 5551 Human UniProt ID P14222
Background	Perforin is a pore-forming protein found in cytoplasmic granules of cytotoxic T-lymphocytes (CTLs). CTLs bind to cells which express foreign antigens and induce them to lyze. Perforin forms circular lesions on the target cell membrane similar to those induced by complement. Perforin and C9 share a high degree of homology particularly at the membrane spanning region. Perforin is reported to be constitutively expressed in human CD3 negative, CD56 positive NK cells, CD3 positive large granular lymphocytes and gamma/delta T cells. This expression is significantly induced in CD8 positive T cells but to a lesser extent in gamma/delta T cells and NK cells. The induction of perforin mRNA is partially blocked by the immunosuppressive drug cyclosporin A.
Synonyms	cytolysin; FLH2; HPLH2; MGC65093; OTTHUMP00000019759; P1; PFN1; PFP
Reference Data

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