MITF Mouse Monoclonal Antibody [Clone ID: 34CA5]

Specifications

Product Data
Clone Name	34CA5
Applications	IHC
Recommend Dilution	1:10 - 1:20
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to 111 amino acids of the N-terminal region of the MITF-M molecule
Specificity	Human microphthalmia transcription factor, MITF-M isoform
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	melanogenesis associated transcription factor
Database Link	Entrez Gene 4286 Human UniProt ID O75030
Background	Microphthalmia transcription factor (MITF) gene product, a nuclear transcription factor of the basic-helix-loop-helix type, is thought to play a role in the regulation of genes encoding the enzymes necessary for melanogenesis. These include tyrosinase, TRP-1 and TRP-2. MITF is critical for the embryonic development and postnatal viability of melanocytes. The melanocyte-specific isoform of microphthalmia transcription factor MITF-M, is reported to be expressed in normal and malignant melanocytes. The other isoforms, MITF-A, MITF-C and MITF-H, differ structurally at the N-terminus from MITF-M.
Synonyms	bHLHe32; MI; WS2A
Reference Data

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