Geminin (GMNN) Mouse Monoclonal Antibody [Clone ID: EM6]

Specifications

Product Data
Clone Name	EM6
Applications	IHC
Recommend Dilution	1:40
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A prokaryotic recombinant protein containing amino acids 5–209 of the mature protein
Specificity	Human Geminin
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	geminin, DNA replication inhibitor
Database Link	Entrez Gene 51053 Human UniProt ID O75496
Background	Geminin is a protein of 209 amino acids thought to be involved in the control of DNA replication via the interaction with Cdt1. Geminin is not found in the G1 phase of the cell cycle, but is first expressed in the G1 to S transition phase, with expression levels rising through the rest of the cell cycle and levels reaching a maximum during mitosis. It has been proposed that geminin may be a tumor suppressor protein. Geminin is reported to be expressed in proliferating lymphocytes and epithelial cells, for example, germinal centers in tonsil as well as in colon, spermatocytes, seminiferous tubules of the testes, within the basal layers of the squamous epithelium of the skin and breast. Geminin is reported to be upregulated in cancers such as non-Hodgkin's lymphoma, B cell lymphoma, breast carcinoma and colon carcinoma.
Synonyms	Gem; geminin; RP3-369A17.3
Reference Data

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