Folate Binding Protein (FOLR1) Mouse Monoclonal Antibody [Clone ID: BN3.2]

Specifications

Product Data
Clone Name	BN3.2
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to 189 amino acids of the external domain of the folate receptor alpha molecule
Specificity	Human folate receptor alpha
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	folate receptor 1 (adult)
Database Link	Entrez Gene 2348 Human UniProt ID P15328
Background	Folate is a basic component of cell metabolism and DNA synthesis and repair. It is involved in essential one-carbon transfer reactions and is a vitamin required by both normal and tumor cells. Folate entry into cells is facilitated via two different systems: the reduced folate carrier, which utilizes a bidirectional anion-exchange mechanism, and the folate receptor system. Folate receptor alpha is a membrane-bound member of the folate receptor family, facilitating folate transport via a mechanism termed potocytosis where the receptor is internalized and then recycled back to the cell membrane. Staining patterns are both membranous and cytoplasmic due to this mechanism. Members of the folate receptor family share highly conserved sequences in the open reading frames, but differ in amino acids in the 5' untranslated regions and as a consequence can differ in function and tissue expression. Folate receptor alpha expression is reported to be highly restricted in normal tissues and only selectively overexpressed in a limited number of epithelial malignancies.
Synonyms	FBP; FOLR; FR-alpha
Reference Data

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