CD38 Mouse Monoclonal Antibody [Clone ID: SPC32]

Specifications

Product Data
Clone Name	SPC32
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant fusion protein corresponding to the extracellular region of the CD38 molecule
Specificity	Human CD38 molecule
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	CD38 molecule
Database Link	Entrez Gene 952 Human UniProt ID P28907
Background	The CD38 molecule is a type II single transmembrane glycoprotein with a molecular weight of 46 kD. It is an ectoenzyme with the activities of ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, NAD glycohydrolase and is involved in both the formation and hydrolysis of cADPR, a second messenger that regulates the mobilization of intracellular Ca2+ ions. Although the CD38 molecule was originally identified as a T lymphocyte differentiation antigen, it is reported to be expressed in a wide range of cells and tissues. CD38 antigen can deliver potent growth and differentiation signals to lymphoid and myeloid cells. It is found on immature cells of the B and T cell lineages but not on most mature resting peripheral lymphocytes. It is also present on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, Ig-secreting plasma cells, monocytes, NK cells, erythroid and myeloid progenitors in the bone marrow and brain cells. CD38 antigen has also been reported in neurofibrillary tangles, the pathological indicator of Alzheimer's disease that occurs in the neuronal perikarya and proximal dendrites.
Synonyms	T10
Reference Data

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