BCL2 Mouse Monoclonal Antibody [Clone ID: BCL-2/100/D5]

Specifications

Product Data
Clone Name	BCL-2/100/D5
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	B cell specific octamer binding protein-1 molecule
Specificity	Human bcl-2 oncoprotein
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	B-cell CLL/lymphoma 2
Database Link	Entrez Gene 596 Human UniProt ID P10415
Background	Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway. In 90% of follicular lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21, to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.
Synonyms	Bcl-2; OTTHUMP00000163680
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.