LIGHT (TNFSF14) Mouse Monoclonal Antibody [Clone ID: 8D4]

Specifications

Product Data
Clone Name	8D4
Applications	FC, IF, IHC, WB
Recommend Dilution	WB start at 0.5 - 1 ug/mL. IHC start at 2 - 5 ug/mL. IF start at 20 ug/mL.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	LIGHT antibody was raised against the extracellular domain of human LIGHT.
Formulation	LIGHT Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	LIGHT Antibody is supplied as protein A purified IgG2b.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 26 kDa.
Gene Name	tumor necrosis factor superfamily member 14
Database Link	NP_003798 Entrez Gene 8740 Human UniProt ID O43557
Background	LIGHT Antibody: LIGHT, also known as Tumor Necrosis Factor Superfamily member 14 (TNFSF14), is a co-stimulatory molecule that can regulate T-cell activation and has recently been identified as an immune checkpoint protein. LIGHT binds to two different receptors, Herpes Virus Entry Mediator (HVEM) and Lymphotoxin beta Receptor (LTbR). While LIGHT binding to HVEM delivers a co-stimulatory signal to T cells , LIGHT binding to LTbR is critical for the formation of lymphoid structures which can stimulate T cell infiltration and activation of a tumor microenvironment, leading to rapid T cell-mediated tissue destruction. It has been shown that targeted delivery of LIGHT to tumors, thereby causing the T cell infiltration of the tumor, can enhance the response of the PD-1/PD-L1 checkpoint blockade anti-cancer therapy,suggesting that LIGHT may become a potent tool in anti-cancer treatment.
Synonyms	CD258; HVEM-L; HVEML; LIGHT; LTg; TR2
Reference Data

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