TIGIT Mouse Monoclonal Antibody [Clone ID: [7E5]]
CAT#: TA355107
Mouse Monoclonal Anti-TIGIT Antibody [7E5]
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CNY 3,080.00
Specifications
Product Data | |
Clone Name | [7E5] |
Applications | FC, IF, IHC |
Recommend Dilution | IHC start at 2 - 5 ug/mL. IF start at 20 ug/mL. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | TIGIT antibody was raised against the extracellular domain of human TIGIT. |
Formulation | TIGIT Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | TIGIT Antibody is supplied as protein A purified IgG2b. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | Predicted: 26 kDa. |
Gene Name | T-cell immunoreceptor with Ig and ITIM domains |
Database Link | |
Background | TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses .Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer . |
Synonyms | DKFZp667A205; FLJ39873; VSIG9; VSTM3; WUCAM |
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