SRPK1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1-2µg/mL.IHC: 5µg/ml.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SRPK1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human SRPK1. The immunogen is located within the first 50 amino acids of SRPK1.
Formulation	SRPK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	SRPK1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 54, 72, 91 kDa; Observed: 91 kDa
Gene Name	SRSF protein kinase 1
Database Link	NP_003128 Entrez Gene 6732 Human UniProt ID Q96SB4
Background	SRPK1 and SRPK2, two Arginine/serine-rich (SR) protein-specific kinases constitute control circuits to regulate both constitutive and alternative pre-mRNA splicing and coordinate splicing with transcription in cells (1). They are highly specific for the phosphorylation of these RS proteins, and highly expressed in testis (1,2). SRPK1 plays a role in the condensation of sperm chromatin and controls the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis (3,4).
Synonyms	SFRSK1
Note	SRPK1 antibody can be used for the detection of SRPK1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry at 5 µg/ml.
Reference Data

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