DIS3L2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1-2µg/ml.IHC starting at 5µg/mL.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	DIS3L2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DIS3L2. The immunogen is located within amino acids 720 - 770 of DIS3L2.
Formulation	DIS3L2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	DIS3L2 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 97 kDa; Observed: 94 kDa
Gene Name	DIS3 like 3'-5' exoribonuclease 2
Database Link	NP_689596 Entrez Gene 129563 Human UniProt ID Q8IYB7
Background	The exosome is involved in a multitude of cellular RNA processing and degradation events (1). DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2). DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3). DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4). DIS3L2 mutations have also been associated with sporadic Wilms tumors (3).
Synonyms	FAM6A; FLJ36974; MGC42174; OTTHUMP00000203808
Note	DIS3L2 antibody can be used for detection of DIS3L2 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Reference Data

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